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Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models

The first step in glutamine metabolism requires entry into the interior of tumor cells

10.1016/j.molcel.2018.11.035 95 PaekJ.KalocsayM.StausD

This makes sense because the liver is the primary organ responsible for detoxification

Pickart L, et al

Bazinet A, Garcia-Manero G, Short NJ, Alvarado Valero Y, Abuasab T, Islam R, Montalbano K, Issa GC, Maiti A, Yilmaz M, Jain N, Masarova L, Kornblau SM , Jabbour EJ, Montalban-Bravo G, Pierce S, DiNardo CD, Kadia TM, Daver N, Konopleva M, Kantarjian HM, Ravandi F