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In rats, R -lipoic acid was more effective than S -lipoic acid in enhancing insulin-stimulated glucose transport and metabolism in skeletal muscle (110), and R -lipoic acid was more effective than R,S -lipoic acid and S -lipoic acid in preventing cataracts (111)

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CISD3 inhibition drives cystine-deprivation induced ferroptosis

However, potential side effects can occur, particularly with intravenous administration

Unless otherwise stated, all experiments were performed in 50 mM KPi, pH 7.4