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Research Evidence Context Published human GHK-Cu research has primarily evaluated topical and wound-care formulations [1] [2] [3] [4] [5] , while local administration in an animal wound model provides additional preclinical context [6]

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NNMTs role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD) stores

While this research is extensive and consistently positive, the gap between animal and human studies represents both a limitation of current knowledge and an opportunity for future research

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