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The dermal route is much more critical for larval fish or embryos, which have thinner, more permeable skin than adult fish ( FIGURE 2 Then the blood circulation distributes the xenobiotics around the body, and they undergo chemical alteration through metabolism or the biotransformation process within the organisms body, which accelerates their removal through excretion (Flanagan et al., 2020)

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However, conflicting evidence exists regarding the use of NOX as a therapeutic target in ALS (Marrali et al., 2014

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