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Uridine alleviating the need to increase mitochondrial biogenesis led us to conclude that increased pyrimidine salvage (probably via UCK2) is driving this mitochondrial adaptation

Mannes AM, Seiler A, Bosello V, Maiorino M, Conrad M

10.1016/j.tet.2007.06.085 191 PrasadC

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When ERAD capacity is overwhelmed or dysfunctional, unresolved ER stress ensues, driving metabolic dysregulation and disease progression (Fig