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This mechanism explains why users often report improvements in stubborn fat deposits that had not responded adequately to diet and exercise alone

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Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C