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Mercapturic acids in the biological monitoring of occupational exposure to chemicals

The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

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Further characterizations suggested that cyst(e)ine regulates GPX4 expression through the RagA/B-mTORC1-4EBP axis

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