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Two Phase 3, multicenter, randomized, double-blind, placebo-controlled trials (LIPO-010 and LIPO-011) enrolled 816 HIV-infected patients with lipodystrophy

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In brief, the production of ketone bodies (mainly acetoacetate and -hydroxybutyrate) from fatty acids serves as an alternative energy supply from the liver to peripheral tissues when carbohydrates are unavailable, therefore being pronounced during fasting or starvation [166]

Copper balance: Extended daily injectable use accumulates copper over time