As previously established, the liver relies heavily on glutathione conjugation (via Glutathione S-Transferases) to neutralize and excrete toxic intermediates, including excess inflammatory mediators and circulating histamine
The discovery that bacteria use secretins as the OM gate for EPS secretion prompts the question whether this mechanism represents a completely novel type of EPS secretory pathway, or whether the secretin is used as the OM component of other, already known, EPS secretion systems 7,30
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Glutathione oxidation-reduction (redox) cycle The figure illustrates the glutathione oxidation-reduction (redox) cycle
Mitochondria are particularly vulnerable to oxidative damage, and they maintain their own glutathione pool
Invest 127 , 750760 (2017)