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doi: 10.3390/pharmaceutics17010119

A large portion is broken down in the gastrointestinal tract before it reaches the bloodstream

intestinal permeability increases, allowing toxic substances or harmful molecules produced by microorganisms to pass through the intestinal surface and enter systemic circulation

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In skin biology, GHK-Cu has been studied for stimulation of collagen types I and III, elastin production and skin elasticity, fibroblast proliferation and directed cell migration, antioxidant enzyme upregulation (SOD, catalase), and wound closure and scar remodeling