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When Ure2p aggregates are formed in vivo , their stability is enhanced and they no longer bind properly the transcription factors, leading subsequently to the expression of genes used for poor nitrogen sources and a slow growth (Edskes et al., 1999

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Annu Rev Plant Physiol Plant Mol Biol 47:245271 Queval G, Jaillard D, Zechmann B, Noctor G (2011) Increased intracellular H 2 O 2 availability preferentially drives glutathione accumulation in vacuoles and chloroplasts