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In conclusion, we have developed and optimized a robust assay to detect LOX-catalyzed modification of ECM proteins to allysines

The mechanism involves Toll-like receptors on dendritic cells, which are the immune system's scouts

Pharmacol Res 118:4352 Samadi A, Soriano E, Revuelta J, Valderas C, Chioua M, Garrido I, Bartolom B, Tomassolli I, Ismaili L, Gonzlez-Lafuente L, Villarroya M, Garca AG, Oset-Gasque MJ, Marco-Contelles J (2011) Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of a-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia

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thus amplifying the response

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