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Biological replicates were repeated in 3 independent experiments

The Journal of Clinical Pharmacology, 2018

The safety profile of cagrilintide, as observed in clinical trials , is primarily characterized by gastrointestinal disturbances , most notably mild to moderate nausea during the initial titration phase

Since this is a common and variable systemic lesion in Fischer-344 rats, the toxicological significance of this finding is uncertain

This study is specifically designed to test cagrilintide by itself in people with a BMI of 30 or higher, or 27 and above with related health conditions