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Data availability The data that support the findings of this study are openly available in TCGA database of PTCs utilizing the Firehouse web browser from the Broad Institute ( using TIMER2.0 ( a computational software for analyses of tumor immunologic, clinical, and genomic features 35

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These apparently opposing effects highlight that the impact of GSH-linked thiol modifications on pyroptosis is highly node-specific and should not be viewed as uniformly anti-inflammatory