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doi: 10.1164/ajrccm/148.3.713

10.3390/nano13152224 111 GeorgeA.ShrivastavP

These senescent cells release harmful pro-inflammatory signals, known as the senescence-associated secretory phenotype (SASP), that damage surrounding tissues and disrupt overall organ function

Studies of AD mouse models have indicated that amyloid-beta and tau-related neurodegeneration in the hippocampus, prefrontal cortex, and anterior cingulate cortex are correlated with NPS-like behavioral deficits