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Such symptoms have resulted from the over-stimulation of the thyroid due to the induction of hyperthyroidism through exogenous thyroid hormones and in turn cause excessive secretion of thyroid hormones, which disturb the feedback loop of the hypothalamic-pituitary-thyroid axis (Bao et al

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Protons (H + ) are pumped across the inner membrane to create an electrochemical gradient, and the energy released when the protons flow back into the mitochondrial matrix drives ATP synthesis by ATP synthase, converting ADP and inorganic phosphate (P i ) into ATP