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Hyun Keol Pyo, et al

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In the heart, histamine increases the force of contraction, and even as far back as 1913, histamine has been known to induce heart arrhythmias.[ref][ref] Mast cells and histamine release: Mast cells are a type of immune cell that creates and stores histamine

doi: 10.1200/JCO.2009.26.6650

Greenberg B, Butler J, Felker GM, Ponikowski P, Voors AA, Desai AS, et al