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2) Administration of glutathione precursors was found to increase cellular stores of glutathione and ultimately protect the skin from oxidative and environmental stress

These observations, reflecting regulatory effects on the transcriptional control of transporters affecting brain UA, demonstrate tissue-specific effects on UA activity, which further question the validity of MR studies discussed above

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Thus, we identify 15LO1 pathway activity in vitro as a prime driver of lower intracellular reduced GSH levels and export of GSSG