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Cultivation of lipopolysaccharide- or TNF--stimulated mesenchymal stem cells of C3H/10T1/2 mice with 5 mM Mg 2+ increased the proliferation rate, decreased the levels of pro-inflammatory IL-1 and IL-6, and increased the levels of anti-inflammatory IL-10 and prostaglandin E2 (136)
These environmental factors may induce epigenetic modifications, which connect changed patterns of gene expression to their surroundings
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