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Description

The TM1 stalk (135-138) of CTR in the Cagri CT-like conformation also undergoes rearrangement relative to the bypass conformation, in which the phenyl of F137 1.28 packs against F15 Cagri , H18 Cagri and S19 Cagri (Fig

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Nevertheless, TMZ faces pharmacokinetic challenges, including a short plasma half-life (~2 hours), susceptibility to P-glycoprotein (P-gp) efflux, and limited penetration across the blood-brain barrier (~20%) (70)

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The Evolution of Complex Organs

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miRNAs modulate autophagy by directly targeting the mRNAs of ATGs or by regulating the transcription factors essential for controlling autophagy

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Hajjar, I., Zhao, P., Alsop, D

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