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Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway

Resources (e.g., nutrients, energy, antioxidants) are limited, thus allocation of a key resource to one trait, such as resistance against viral infection, means that less can be allocated to other functions that might be important in terms of Darwinian fitness (e.g., fertility)

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In general, BCRP substrates share a same set of molecular properties as that of substrates to P-gp and other efflux pumps (Begley 2004, Kunta and Sinko 2004, Takano et al