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Its not something new: it was introduced around 1950 and today it can be used up to 1% worldwide

Treatment Frequency Depending on the patient, some protocols involve a daily administration, administration of three to five doses weekly, or administration on a rotating schedule

In addition, how the supplementation dose of small molecular antioxidants affects their intracellular levels and whether radical scavenging activity at the site of action is feasible are unknown

and decreased mitochondrial aconitase activity and mitochondrial membrane potential are observed in HepG2 lines overexpressing CYP2E1 in mitochondria (mE10 and mE27 cells) treated with BSO as compared with cells transfected with empty vector (pCI-neo) [5]

doi: 10.3389/fgene.2015.00148

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