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Evidence in humans remains early and limited

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The link between GST overexpression, especially with respect to GSTP1, and anticancer drug resistance has been extensively studied

189 In an uncontrolled trial that included 119 men with idiopathic infertility, supplementation with a multi-nutrient cocktail containing vitamins, minerals, and several antioxidants twice daily for three months led to significant improvements in sperm concentration, motility, morphology, and DNA fragmentation compared with pretreatment analyses

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In fact, most clinicians interpret depression as a monoamine neurotransmitter imbalance, making serotonin, dopamine and/or adrenaline the primary targets for most conventional first-line antidepressant treatments