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In iron-deficient states, GPX4 activity declines, leading to reactive oxygen species (ROS) accumulation and lipid peroxidationpotent triggers of eryptosis (Rochette et al., 2022)

doi: 10.1007/s00259-019-04543-w 73 MilanGReemaGSimoneKKevinDSJamesJHIngoKMet al

The hidden bulk depicts impaired mitochondrial biology throughout the body, which is multifaceted and may be subdivided into impaired cellular metabolism, cell-specific mitotypes, and mitochondrial behaviours, functions, activities, and features

10.1016/j.biomaterials.2008.04.002 155 RaoA

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Mice were percutaneously exposed for 1 h to about 80 S