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Nevertheless, further mechanisms can induce the chronic worsening of renal function, thus leading to terminal kidney failure as observed in post-hoc analysis from registration trials and dedicated observational studies

[36] Jayaram, L., King, P.T., Hunt, J., Lim, M., Park, C., Hu, E

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In Wistar rats, shifts in light exposure altered peripheral clock gene expression and increased inflammatory markers and estrogen receptor expression in white adipose tissue, suggesting that circadian disruption may enhance estrogen-mediated pathways, which are known to be involved in breast carcinogenesis 201

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