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doi: 10.1016/j.cellimm.2017.02.006 67 JohnPWeiYLiuWDuMGuanFZangX

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This coordination is mediated by (i) inter-organ substrate cycles, (ii) endocrine/paracrine signaling by adipose-, liver-, and muscle-derived factors (lipokines/adipokines, hepatokines, myokines), (iii) canonical pancreatic hormones, and (iv) extracellular-vesicle transfer of miRNAs and other regulatory cargo

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