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GSH biosynthesis, as well as relying on NADPH, relies on the amino acid cysteine (68)

Ethics statement The studies involving humans were approved by USC Institutional Review Board

When a research timeline extends past six weeks, common practice is splitting the reconstituted solution into single-use volumes and freezing them at 20 C immediately

While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

Abstract Brassica species contains sulfur-containing secondary compounds including glucosinolates which might protect plants from pathogens

Compared to mammalian 3-MST, Leishmania 3-MST contains an additional 70 amino acids in the C-terminal domain