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Repeated use of the same site can cause lipohypertrophy or tissue changes that increase discomfort

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Peptide compounds mentioned are referenced for educational context only

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The authors (Khavinson and two other Russian researchers) found that epitalon produced impressive antioxidant effects, and perhaps even more crucially, simultaneously stimulated the expression of additional antioxidant enzymes such as ceruloplasmin, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase (SOD)

Based on clinical studies, the reported tolerability of orally administered extracts of Centella is high, and no interactions with other drugs are known