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Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al

Author(s): 1Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran 2Department of Biology, Concordia University, Montreal, Canada Published online:Jun 30, 2025 Article type:Review Article Received:May 12, 2025 Accepted:Jun 25, 2025 How to Cite:Abd Nikfarjam B, Hajiaghayi M

10.1007/s40883-019-00113-6 143 PatelM.JhaA.PatelR

Why Opioids Backfire With Repeated Use With repeated exposure, the nervous system adapts to opioids, leading to: Tolerance , requiring higher doses for the same effect (33,35) Dependence , with withdrawal symptoms when doses wear off (35) Opioid-induced hyperalgesia , a paradoxical increase in pain sensitivity (33,36) Rather than calming pain long term, opioids can sensitize the nervous system, making everyday stimuli feel more painful (33,36)

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