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GCL is in part regulated by GSH feedback inhibition, thus if GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated, as is cysteine synthesis

Additionally, certain peptides can stimulate the release of gonadotropin-releasing hormone to enhance muscle growth and fat loss

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Previous studies have demonstrated that FUS-induced BBB opening may trigger CNS immune-regulation to facilitate A clearance 7,8 and animal behavioral functions can be restored 6,7