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IGF-1 binding to insulin-like growth factor receptors can activate downstream IRS and promote angiogenesis through the MAPK and PI3-K pathways [21, 38, 39]

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Thus, the limitations of current diagnostic approaches and the wide-spread use of this analgesic make it imperative to discover and validate sensitive and specific translational biomarkers of APAP-induced liver injury

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Genetic rearrangements among the RET tyrosine kinase domain and heterologous genes are the root of RETs carcinogenic potential in PTC

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