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NMR reveals a novel glutaredoxinglutaredoxin interaction interface

There are many promising drugs targeting altered metabolism pathways undergoing disparate stages of preclinical studies and clinical trials ( Table 2 )

doi: 10.1002/biof.5520320124 21

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Neuronal effect High oxygen utilization, huge amounts of polyunsaturated fatty acids, elevated levels of free iron ions and low antioxidants defenses all together make the brain tissue vulnerable to reactive oxygen species injuries (48)