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Furthermore, loss of neurogenesis, whether it be a result of age or injury, mainly results from decreased survival or proliferative capacity of the different NSC populations, with activation of the NRF2 pathway clearly playing a protective role

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Dardenne M, Pleau JM, Nabarra B, Lefrancier P, Derrien M, Choay J, et al

Toxicity of glutathione-binding metals: A review of targets and mechanisms