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Tirzepatide : SURPASS trials showed HbA1c reductions of up to 2.58% (15 mg) with 52% achieving normal HbA1c below 5.7%

Peptides can be a part of that

however, many clinical trials fail, and patients experience an unsatisfactory treatment response, likely owing to IC/BPS phenotype heterogeneity and the use of non-targeted interventions