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In accordance, newborns with mutations in the GH Releasing Hormone Receptor (GHRHR) gene resulting in an isolated GH deficiency (GHD) phenotype was associated with normal birth weight in one cohort (53) and slightly subnormal birth weight in another (54)

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For a comprehensive assessment of cardiometabolic risk alongside these performance markers, the Heart Vitality Panel adds important context, particularly in older patients for whom metabolic and cardiovascular risk tracking should proceed in parallel

4 Treatment groups Experimental Treatment Active Control Placebo Group Participants will receive cagrilintide and semaglutide once-weekly after a dose escalation period of 16 weeks during the maintenance period for 52 weeks in the main phase