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The resulting oxidative stress promotes Drp1-mediated mitochondrial fission, mPTP opening, and membrane depolarization, thereby amplifying apoptotic signaling [52, 138]

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To test this hypothesis, we co-cultured GGT1 + cells with WT cells using a Transwell assay (Fig

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GLOBAL GLUTATHIONE MARKET SIZE, BY SUN CARE, BY REGION, 2018-2032 (USD MILLION) TABLE 31

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While preliminary evidence suggests a potential role of this mechanism in ovarian cell function, further studies are needed to clarify the underlying regulatory pathways and physiological significance

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9 Acquired 5FU resistance is associated with increased mitochondrial content and signaling

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