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All analyses were controlled for age, total calorie intake, physical activity level, BF%, medicine status, alcohol intake, smoking status and menopausal status

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10.1016/j.intimp.2022.108717 Int Immunopharmacol

A review study proposed another mechanisms underlying the potential interaction of the smoking and oestrogen metabolites such as decrease in oestrogen activity, SHBG levels, aromatase enzyme activity, C-20, 22 desmolase enzyme levels and increase in free testosterone levels, hyperandrogenism and the hepatic metabolism of steroid (Reference Ruan and Mueck41)

Since GHK-Cu levels decline naturally with age, ongoing supplementation helps maintain the gains achieved during intensive treatment phases

It's often used in sunscreens as it's also an excellent solvent for sunscreen agents