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AOD-9604 operates independently of GH receptors and doesn't engage the broader GH signaling cascade that produces IGF-1 elevation

After a 2D classification with a binned dataset in CRYOSPARC, a homogeneous subset of particles was re-extracted as the native pixel sampling and subjected to Bayesian particle polishing in RELION, followed by another further 2D classification in cryoSPARC

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No severe or serious adverse events were observed with combination cagrilintide and semaglutide