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Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo

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Furthermore, PFKFB3 expression can affect the survival rate of OA chondrocytes by regulating the expression levels of P-Akt and CHOP, which can be restored by PI3K inhibitor

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It is a ubiquitous enzyme that catalyzes the NADPH dependent reduction reaction of oxidized glutathione (GSSG) to reduced glutathione (GSH)

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