Satarug S, Garrett SH, Sens MA, Sens DA
Initially recognized as the primary protease in mitochondria, caspase-2 is now known to be activated by both calpain and caspase-3, triggering caspase-9 in the process [30]
We combined these novel patient-derived hepatocyte organoids with primary human portal mesenchyme and human cholangiocyte organoids (h-CholOrgs) from the same patient to generate human periportal assembloids that recapitulate the functional cell interactions and architecture of the in vivo tissue
Chu FF, Doroshow JH, Esworthy RS
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