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Cell Stress Chaperon (2016) 21:68796

Korobchevskaya,K., Lagerholm,C

The extrapineal biosynthetic locations include the retina, harderian gland (complementary to the lacrimal), bone marrow, skin, cerebellum, cells of the immune system (lymphocytes), and particularly cells of the gastrointestinal tract that produce serotonin

Mice were euthanized at humane end points (when the tumour diameter exceeded a total of 20 mm in length, when ulceration occurred or when weight loss exceeded 20%)

This high GSH/GSSG ratio ensures a reducing cytosolic redox potential, and most cytosolic sulfhydryl groups are present as free thiols rather than oxidized disulfides