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These active sites react with peroxide to make selenenic acid (Se-OH), which is then reduced into glutathione (GSH) by the glutathione reductase (GR) enzyme to produce glutathiolated selenol (Se-SG) intermediate

6.3 Inhibition of bone destruction and cartilage damage Clinical trials have shown that the use of tocilizumab in combination with methotrexate in patients with moderate-to-severe RA can significantly decrease the level of the bone remodeling markers, C-terminal cross-linked telopeptide of type I collagen and MMP-degraded type II collagen, and inhibit the bone remodeling process (282)

Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1

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10.1249/mss.0b013e3180616aa2 219 NelsonA