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Backed by clinical studies, such as those by Leyden et al

Gastroenterology 137, 18271835

The patient was reduced to social withdrawal, infrequent smiles, and little intelligible speech

While the compound has shown efficacy in animal models, he notes that more research is needed to fully understand the risks and benefits for human use, especially over extended periods

Thus, the inhibition of p52 by metformin results in the ability of the PDE4B gene to remain transcriptionally active leading to reductions in the level of cAMP and reduced activation of PKA

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