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Compounds under screening were added for 1.5 hours as pretreatment and then as co-treatment with cisplatin for 22 hours

3 is used to illustrate the mechanism of the interaction between glutathionyl cobalamin and 5-methyltetrahydrofolate to form methylcobalamin

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Once opened, or after reconstitution, repeated exposure to air when drawing out doses can introduce oxygen, leading to oxidative degradation