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Yet the deeper story of GHK-Cuits influence on gene expression, tissue remodeling, and regenerative signalingsuggests that we may only be beginning to understand the full potential of this small but biologically powerful peptide

The SVM classifier has achieved fair efficiency, with a precision of 89.29%, a recall of 89.14%, an F1-score of 89.33%, a G-measure of 89.11%, and an accuracy of 89.23%

Protocol heterogeneity is a pervasive confounder and a common reason for failed transportability

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Future research must therefore pivot toward integrated, multi-targeted nutritional strategies that simultaneously address these interconnected pathways, moving beyond single-nutrient approaches to achieve personalized OA management (35)

Notably, the Hamilton Depression Rating Scale (HAMD-17) scores in this population correlate strongly with biomarkers of hepatic dysfunction (e.g., elevated gamma-glutamyl transferase) and neuronal injury (e.g., serum neurofilament light chain), suggesting a unique pathophysiology blending systemic and central nervous system (CNS) toxicity (Mirabdolhagh Hazaveh et al