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Since the hallmark of SCD is chronic hemolysis with excess hemin producing significant levels of oxidative stress, we speculate that hemin may modulate TSS pathway function

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Further, we found NRF2 to be dispensable to the liver upon GSH depletion

Anti-aging benefits Glutathione helps slow the effects of aging by combating oxidative stress at the cellular level

doi: 10.1038/s41598-023-39279-z 145 WangWLinFShiSYuYLinMLianWet al

Hepatic macrophages have critical roles in the initiation and progression of fibrosis (93, 196, 197)