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In the earliest iterations, monolayer endothelial cells alone (BBB-on-chip) or with astrocytes and pericytes (NVU-on-chip) were cultured as in transwell systems (Jiang et al., 2019)

As a proposed zonulin antagonist and tight-junction regulatory peptide, the use of LA may prove useful for other patient indications given current data in both small and large animal models of injury

VEGF upregulation supports blood vessel formation that could theoretically feed tumor growth

The FDA has already signaled openness to reducing mandatory animal testing requirements where validated alternatives exist, accelerating the transition from preclinical to first-in-human studies

PMID: 37242459

The material is supplied in sealed laboratory vials to assist analytical investigations, assay development, and experimental protocols in professional environments where documentation and reproducibility are essential