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In addition, the AIM-HIGH trial demonstrated that the concurrent use of extended-release niacin (1500-2000 mg/day PO) and simvastatin does not result in a greater reduction in the incidence of cardiovascular events than simvastatin alone

doi: 10.1007/s11306-022-01886-8 6 BanachM.GurdzielE.JdrychM.BorowiczK

Healy et al., 1970