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Functional enrichment indicated strong activation of iron transport and lipid peroxidation pathways, but weak engagement of glutathione metabolism, suggesting selective vulnerability to iron-driven oxidative stress

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Statistical analysis For all studies, Students t -test or Wilcoxon rank sum test was performed to compare the differences between two groups

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FOXO4-DRI is primarily investigated in cellular aging, senescence biology, and longevity-related research contexts

Figure 2f) or perpendicular to the helices 2 and 3 (Fig