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The NLRP3 inflammasome is a critical component of the innate immune system responsible for detecting cellular stress and damage signals

Thus, genetic engineering to enhance GPX4 expression in NK cells may prolong their survival and activity in the harsh TME, opening new avenues for NK cell-based immunotherapy (76)

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Mitochondrial Complex I Inhibition Triggers a Mitophagy-dependent ROS Increase Leading to Necroptosis and Ferroptosis in Melanoma Cells